I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. (One such knockoff, Pet Armor Plus, is even available at Walmart.). Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. And use same collar for a few months. This organic powder is great for a variety of uses. Congratulations on the new kitten. We have an 11 year old tricolor rough coat collie. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. Please let me know how the Wondercide works for you! That way if a tick does make it past the essential oil barrier and bite, itll die anyway. Dogs with the MDR1 mutation are therefore safe in getting a monthly dosage of an ivermectin product like heart guard considering that it only contains . We often go on walks in the woods. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The active ingredients in Seresto are entirely different from those in Frontline, however. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). A1443) is a novel systemic ectoparasiticide and belongs to the class of isoxazolines, also including afoxolaner, lotilaner and sarolaner [ 1, 2 ]. I have never even heard of the latter and do not believe they exist in Canada. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. Some products are considered safe for use during pregnancy and lactation, while others may not be recommended. The FDA thinks this drug is safe to use on your dog. Is it safe to give an occasional one to him even though hes on Bravecto 1-month? While my pain levels went down, I noticed that my heart rate went up! Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. Use These Products Infrequently, Only as Needed Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. Thats why I use it in combination with an essential oil spray like Natural Chemistry. This can be orally administered to the dogs, which are safe and remain effective for one full month. Thank you for writing this article. The best thing about Seresto is how long it can do its job up to 8 months! Im hoping to get a Smoothie myself in the future. The following list shows the common dog breeds most likely to have the MDR1 mutation, and the percentage affected in each. Consumed by free choice or with food 91.9% of the time See the Simparica Trio difference Compare the labels of other products with Simparica Trio * by killing deer ticks Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. Luckily, Simparica Trio for dogs is considered fairly safe. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes.) I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! If your dog vomits within two hours of taking Simparica, please contact your veterinarian. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Thanks. The Seresto collar is a very popular option right now. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. Simparica TRIO (6.0 mg/0.12 mg/25. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! Due to this fact, Pet Place warns: Is Simparica Safe For Dogs? If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. Personally, I would be concerned about missing a daily dose. I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. , Thanks for the reply! If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. Hope this helps! Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. They were constantly scratching, and the symptoms did not subside until I washed it off. Id like to have a Smooth Collie in the future. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. She was obviously in discomfort. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. . THANK YOU, THANK YOU, THANK YOU! . The manufacturer of Revolution has tested the product for safety in dogs with the MDR1 mutation. This paper detailed a study done using 16 collies, eight males and 8 females. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. Thank you for this. Hope this helps! My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Plus, Simparica's protection lasts for five weeks (35 days), and it does not decrease at the end of the month. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. Yes, Simparica is a good flea treatment for dogs. Best of luck with your girl! Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. Personalizing your pets health care. Additionally, it can also be given to cats and even pregnant or nursing animals. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. What an awesome article. Basically, the idea is that heartworms take a few months to develop anyway, so every few months you get your dog tested instead of merely annually and ONLY treat for heartworms if bloodwork reveals that your dog has contracted heartworms. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. Your thoughts? My entire world: Nola Riley and Otis Kai: ) Nola is MDR1-Heterozygous given cats. Scared to use on your dog however, its technically safe so long it! Ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose how the Wondercide works you... It past the essential oil barrier and bite, itll die anyway Kai: ) Nola MDR1-Heterozygous... Levels went down, I would be concerned about missing a daily dose, though the downside is its! 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