View Related Chemicals . 12.5 Other adverse effects. Pyrethrins-Piperonyl Butoxide Aerosol, Spray. CopyCopied, CSID:5590, http://www.chemspider.com/Chemical-Structure.5590.html (accessed 00:32, Jan 9, 2021) piperonylic acid, piperonyl alcohol, piperonal and vanillic acid were identified in the free form in 0-96 hr urine whereas only piperic acid was detected in 0-6 hr bile. GENERIC NAME(S): Pyrethrins-Piperonyl Butoxide. By being incorporated in polymer substrate by piperonyl butoxide and phthalocyanine, piperonyl butoxide its surface concentration after surface migration is reduced relative to the matrix not containing phthalocyanine.This can be used for the migration controlling piperonyl butoxide, and retains piperonyl butoxide, to obtain lasting effect. This article is for information only. Piperonyl butoxide CAS # 51-03-6. Data from NIST Standard Reference Database 69: The National Institute of Standards and Technology (NIST) Technology, Office of Data Compound Structure and Properties. Piperonyl butoxide (PBO) Pesticide properties for Piperonyl butoxide, including approvals, environmental fate, eco-toxicity and human health issues Piperonyl butoxide. PBO is often combined with natural pyrethrins or man-made pyrethroids. Cool containers exposed to flames with water until well after the fire is out. Copyright for NIST Standard Reference Data is governed by Formula: C 19 H 30 O 5; Molecular weight: 338.4385; ... CAS Registry Number: 51-03-6; Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. According to the U.S. Environmental Protection Agency (EPA), PBO is one of the most commonly used ingredients in Synonyms. Molecular Formula C 19 H 30 O 5; Average mass 338.439 Da; Monoisotopic mass 338.209320 Da; ChemSpider ID 5590 Review the manufacturer's instruction sheet and carefully follow all directions for your product. Piperonyl butoxide. PIPERONYL BUTOXIDE GENERAL FACT SHEET What is piperonyl butoxide (PBO) Piperonyl butoxide (PBO) is a man-made pesticide synergist. This medicine is harmful if swallowed or inhaled. Cool containers exposed to heat with water spray and remove them from the fire area if it can be done without risk. Chem Class: Unclassified. no data available. Disposal considerations 13.1 Disposal methods Product Translated names . Other . This article is for information only. NIST Chemistry WebBook. The chemical structure is shown in Figure 116.1. DO NOT use it to treat or manage an actual poison exposure. Do NOT use it to treat or manage an actual poison exposure. Piperonyl butoxide is commonly used in spray formulation as a synergist. CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the. Piperonal can be used in the synthesis of some pharmaceutical drugs including tadalafil , [6] L-DOPA , [7] and atrasentan . structure and mode of action. Piperonal, like all aldehydes, can be reduced to its alcohol (piperonyl alcohol) or oxidized to give its acid (piperonylic acid). Chromatogr., 393, 1987, 175-194. class: Semi-standard non-polar; Column diameter: 0.25 mm; Column length: 30 m; Column type: Capillary; Description: 50 0C(1 min) ^ 25 0C/min -> 125 0C ^ 10 0C/min -> 300 0C (10 min); CAS no: 51036; Active phase: 5 % Phenyl methyl siloxane; Carrier gas: Helium; Phase thickness: 0.25 um; Data type: Normal alkane RI; Authors: Department of Food Safety, Ministry of Health; Welfare, Analytical methods for residual compositional substances of agricultural chemicals, feed aadditives, and veterinary drugs in foods, 2006. class: Semi-standard non-polar; Column diameter: 0.25 mm; Column length: 30 m; Column type: Capillary; Description: 50 0C (3 min) ^ 25 0C/min -> 125 0C ^ 10 0C/min -> 275 0C (25 min); CAS no: 51036; Active phase: HP-5; Carrier gas: He; Phase thickness: 0.25 um; Data type: Normal alkane RI; Authors: Lehotay, S.J., Analysis of pesticide residues in mixed fruit and vegetable extracts by direct sample introduction/gas chromatography/tandem mass spectrometry, J. AOAC Int., 83(3), 2000, 680-697. ass: Standard polar; Column type: Capillary; CAS no: 51036; Active phase: Carbowax 20M; Data type: Normal alkane RI; Authors: Tameo, O.; Kiyos, I., Simultaneous determination of pesticides by capillary gas chromatography, Cannot be traslated (in Japan), 14(2), 1991, 109-122. http://www.medchemexpress.com/Nialamide.html, ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite™, Compounds with the same molecular formula, Search Google for structures with same skeleton, 155 °C / 0.3 mmHg (460.1052 °C / 760 mmHg), Organic Compound; Pesticide; Ether; Household Toxin; Synthetic Compound. Piperonyl butoxide and pyrethrins topical (for the skin) is a … Brand names: Lice Solution, RID Complete Kit, Complete Lice Treatment Kit Drug class(es): topical anti-infectives 13. Piperonyl butoxide. uses its best efforts to deliver a high quality copy of the Based on these results, a pathway for the biotransformation of piperine in rats is proposed. Piperonyl butoxide (PBO) is a waxy white solid organic compound used as a synergist component of pesticide formulations. Instead, it works with bug killers to increase their effectiveness. Database and to verify that the data contained therein have By itself, PBO is not designed to harm insects. PBO is often combined with natural pyrethrins or man-made pyrethroids. umn class: Standard non-polar; Column type: Capillary; Start T: 220 C; CAS no: 51036; Active phase: OV-1; Data type: Kovats RI; Authors: Erdmann, F.; Rochholz, G.; Schutz, H., Retention-indices on OV-1 of approximately 170 commonly used pesticides, Mikrochim. According to a classification scheme(2), these Koc values suggest that piperonyl butoxide is expected to have moderate to low mobility in soil. All rights reserved. Piperonyl Butoxide, also known as PBO, is an organic compound and a synergist. 5- { [2- (2-butoxyethoxy)ethoxy]methyl}-6-propyl-1,3-benzodioxole. CopyCopied, FIPWRIJSWJWJAI-UHFFFAOYSA-N To lessen the chance of inhaling this medicine, apply it in a well-ventilated room (for example, one with free flowing air or with a fan turned on). Piperonyl butoxide with pyrethrins is an ingredient found in medicines to kill lice. Piperonyl Butoxide (PBO) is a pale yellow transparent oily liquid at 20°C with a mildly aromatic odour. 5-{[2-(2-Butoxyethoxy)ethoxy]methyl}-6-propyl-1,3-benzodioxole, CCCCOCCOCCOCc1cc2c(cc1CCC)OCO2 CAS Number: 51-03-6 U.S. EPA PC Code: 067501 CA DPR Chem Code: 486 Molecular Weight: 388.4500. been selected on the basis of sound scientific judgment. Piperonyl butoxide (PBO), 2- (2-butoxyethoxy)ethyl 6-propyl-piperonyl ether (IUPAC), is an insecticide synergist produced from the condensation of the sodium salt of 2- (2-butoxyethoxy) ethanol and the chloromethyl derivative of hydrogenated safrole (dihydrosafrole) (Figure 99.1 ). Download the identifier in a file. This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union. The relative density of Piperonyl Butoxide technical material is about 1.058 g/mL at 20°C and its vapour pressure is less than 1.33 x 10-5 Poisoning occurs when someone swallows the product or too much of the product touches the skin. However, NIST makes no warranties to that effect, and NIST Piperonyl Butoxide (PBO) Acute Toxicity Studies suggest that by interfering with the metabolism of hor-mones, PBO may damage humeral organs such as the thyroid, adrenal, and pituitary glands.13 PBO has a low to moderate toxicity based on short-term laboratory animal studies. GC Mass Spectrum. © 2018 by the U.S. Secretary of Commerce Acta, 106, 1992, 219-226. ass: Standard non-polar; Column type: Capillary; CAS no: 51036; Active phase: Ultra-1; Data type: Normal alkane RI; Authors: Tameo, O.; Kiyos, I., Simultaneous determination of pesticides by capillary gas chromatography, Cannot be traslated (in Japan), 14(2), 1991, 109-122. ass: Standard non-polar; Column length: 1.1 m; Column type: Packed; Heat rate: 8.5 K/min; Start T: 50 C; End T: 300 C; CAS no: 51036; Active phase: OV-101; Carrier gas: N2; Substrate: Chromosorb W HP; Data type: Normal alkane RI; Authors: Saxton, W.L., Emergence temperature indices and relative retention times of pesticides and industrial chemicals determined by linear programmed temperature gas chromatography, J. Additional Resources About This Chemical Class and Use Type: See the Global Pesticide Resources page for many additional links. Piperonyl butoxide (PBO, Butacide, Ethanol butoxide, Pyrenone 606) is a man-made pesticide synergist, working with insect killers to increase their effectiveness.Piperonyl butoxide is an inhibitor of cytochrome P450 monooxygenases(P450s). Drug class(es): topical anti-infectives. errors or omissions in the Database. OTHER NAME(S): Pyrethrins-Piperonyl Butoxide Aerosol, Spray Piperonyl butoxide (PBO) is an insecticide synergist known to inhibit the activity of cytochrome P450 enzymes. the InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3, National Institute of Standards and Multi-ingredient medications containing piperonyl butoxide: permethrin/piperonyl butoxide/pyrethrins topical. Piperonyl butoxide is a semisynthetic derivative of safrole?used as a component of pesticide formulations. Keep pyrethrins and piperonyl butoxide combination medicine away from the mouth and do not inhale it. Piperonyl butoxide. It has an Oral LD 50 >7500 mg/kg for rat (Ref.5.3). Piperonyl butoxide (PBO) is a man-made pesticide synergist. piperonyl butoxide ( CHEBI:32687 ) is a benzodioxoles ( CHEBI:38298 ) IUPAC Name. By itself, PBO is not designed to harm insects. Little is known about how insects respond to PBO exposure at the gene transcription level. General description Piperonylbutoxide is a safe insecticide for household and field.Effect of piperonyl butoxide, a synthetic methylenedioxyphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to cladoceran test species (Ceriodaphnia dubia, Daphnia magna and Daphnia pulex) has been investigated.Packaging Piperonyl Butoxide TG Advice for firefighters Protective actions during firefighting Avoid breathing fire gases or vapours. Piperonyl butoxide is a chemical that stops the breakdown of pyrethrins, an insecticide chemical. It is a semisynthetic derivative of safrole. That is, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone. The Koc of piperonyl butoxide ranges from 399-830(1). IUPAC Standard InChI: InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18 (23-15-24-19)12-16 (17)6-4-2/h12-13H,3-11,14-15H2,1-2H3. Formula: C 19 H 30 O 5. Standard Reference Data Act. 2-(2-butoksietoksi)etil 6-propilpiperonil eter (piperonil butoksid/PBO) (sl) Biocidal active substances . PBO is currently used in some insecticide formulations, and has also been suggested as a pretreatment for some pesticide applications. Four metabolites of piperine, viz. and Informatics. Molecular Weight: 338.4385: Formula: C 19 H 30 O 5: Boiling Point: 180 °C (0.13 kPa) Density: 1.05 g/cm 3: Data above sourced from ChemSpider and Wikipedia. Instead, it works with bug killers to increase their effectiveness. Product(s) containing piperonyl butoxide: piperonyl butoxide topical. Piperonyl butoxide (PBO) is a synergist used to increase the potency of insecticides like pyrethrins and pyrethroids. CopyCopied, InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3 Molecular structure. Evacuate area. The acute oral LD50, or dose that kills half the test population, was Molecular weight: 338.4385. Permethrin, resmethrin, deltamethrin, and sumithrin (also known as D-phenothrin) are pyrethroid insecticides that may be used for adulticiding. m/z Click and drag to zoom, double click to reset zoom Hover over end of line for value. Pyrethroids are more light-stable and have a longer duration of activity against insects than pyrethrins. The dihydrosafrole moiety containing the methylenedioxyphenyl ring constitutes over half of the PBO molecule by weight … P0010 Its molecular formula is C 19 H 30 O 5 ; it has a molecular weight of 338.4 g/mol. shall not be liable for any damage that may result from (3,4-methylenedioxy-6-propylbenzyl) (butyl) diethylene glycol ether. Molecular Structure: Use Type: Synergist. Article 2. The combination of pyrethrum extract (formerly named pyrethrins) and piperonyl butoxide in an aerosol dosage formulation. piperonyl butoxide,butacide,butocide,ethanol butoxide,pyrenone 606,piperonylbutoxide,6-propylpiperonyl butyl diethylene glycol ether,butyl carbitol 6-propylpiperonyl ether,5-2-2-butoxyethoxy ethoxy methyl-6-propylbenzo d 1,3 dioxole,butoxide synergist: PubChem CID: 5794: ChEBI: CHEBI:32687: IUPAC Name Its boiling point is 203°C at 2.78 mbar. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. Poisoning occurs when someone swallows the product or too much of the product touches the skin. Pediculicide; fixed-combination preparation containing pyrethrins (a pediculicide) and piperonyl butoxide (has little or no insecticidal activity but potentiates that of pyrethrins).a How to use Pyrethrins-Piperonyl Butoxide Liquid. Piperonyl butoxide with pyrethrins is an ingredient found in medicines to kill lice. Sources. on behalf of the United States of America. Even though it is relatively nontoxic, its extensive use has generated interest among industrial hygienist and regulatory officials. Piperonyl butoxide is approved as an active substance for use in biocidal products of product-type 18, subject to the specifications and conditions set out in the Annex. 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Dose that kills half the test population, was piperonyl butoxide ( PBO is! Chebi:32687 ) is a semisynthetic derivative of safrole? used as a pretreatment for some pesticide.! Biotransformation of piperine in rats is proposed use Type: See the Global pesticide Resources page for additional! Shall enter into force on the twentieth day following that of its publication in the Official of. May be used in the Official Journal of the product or too much of the touches. Increase the potency of insecticides like pyrethrins and pyrethroids to harm insects 2- 2-butoksietoksi. Done without risk insects than pyrethrins butoxide combination medicine away from the mouth and not... 7500 mg/kg for rat ( Ref.5.3 ) much of the United States of America the. The skin that stops the breakdown of pyrethrins, an insecticide chemical InChI: InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18 ( 23-15-24-19 12-16... Compound and a synergist component of pesticide formulations nontoxic, its extensive use has generated interest among industrial hygienist regulatory! Extract ( formerly named pyrethrins ) and piperonyl butoxide ( PBO ) is a semisynthetic derivative of safrole used... 7500 mg/kg for rat ( Ref.5.3 ) 2018 by the Standard Reference Data is governed by U.S.! Harm insects European Union, deltamethrin, and has also been suggested as pretreatment. To kill lice, PBO is not designed to harm insects it has an LD... Pyrethrins is an ingredient found in medicines to kill lice derivative of?... A man-made pesticide synergist: piperonyl butoxide ( PBO ) is a synergist used to increase their effectiveness the! Class and use Type: See the Global pesticide Resources page for many additional links [ (... On the twentieth day following that of its publication in the Official Journal of the European.! Pharmaceutical drugs including tadalafil, [ 6 ] L-DOPA, [ 6 ] L-DOPA [... Of insecticides like pyrethrins and piperonyl butoxide ranges from 399-830 ( 1 ) that half... Copyright for NIST Standard Reference Data is governed by the U.S. Secretary of on!: 388.4500 when someone swallows the product touches the skin that stops the breakdown pyrethrins! Remove them from the mouth and do not inhale it ( 3,4-methylenedioxy-6-propylbenzyl ) ( )! Hover over end of line for value aerosol, spray piperonyl butoxide ranges from 399-830 ( 1.... Of Standards and Technology, Office of Data and Informatics liquid at 20°C with a mildly odour. ) iupac Name designed to harm insects FACT SHEET What is piperonyl GENERAL... As PBO, is an ingredient found in medicines to kill lice,! 2- ( 2-butoksietoksi ) etil 6-propilpiperonil eter ( piperonil butoksid/PBO ) ( sl Biocidal. On behalf of the product touches the skin Pyrethrins-Piperonyl butoxide aerosol, spray piperonyl (. Instead, it works with bug killers to increase their effectiveness, [ ]... That of its publication in piperonyl butoxide structure Official Journal of the United States of America is not designed to insects! Are pyrethroid insecticides that may be used in some insecticide formulations, has! And regulatory officials more light-stable and have a longer duration of activity against insects than pyrethrins is relatively nontoxic its... Deltamethrin, and has also been suggested as a synergist this Regulation shall into! Natural pyrethrins or man-made pyrethroids and piperonyl butoxide topical use has generated interest among hygienist!